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KMID : 0363320080290030629
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 3 p.629 ~ p.640
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Effect of Bambusae Caulis in Liquamen(Jukryuk) on Ischemic Damage to 4 Vessel Occlusion and Middle Cerebral Artery Occlusion in Mice
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Kim Jae-hong
Hong Jin-Woo
Na Byung-jo
Park Seong-Uk
Jung Woo-sang
Moon Sang-Kwan
Park Jung-Mi
Ko Cham-nam
CHo Ki-Ho
Kim Young-Suk
Bae Hyung-sup
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Abstract
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Objective : The purpose of this study was to investigate the neuroprotective effect of Jukryuk on 4-vessel occlusion(4-VO) and middle cerebral artery (MCA) ischemia.
Method : After administration of Jukryuk, we compared the Jukryuk-treated group, the control, and the sham groups, in view of several points as follows 1) We evaluated the damage characterized by coagulative cell change of pyramidal neurons and pronounced gliosis in each group 2) We counted the number of normal pyramidal shapes after ischemia in each group 3) Immunohistochemistry (cyclooxygenase-2) 4) In focal ischemic injury model, we measured the volume of ischemic area
Results : In this experiment, the effect of Jukryuk was determined to be protecting neuron cell shape, reducing the number of neuron cells damaged by ischemia and the volume of the ischemic area. In immunohistochemistry, Jukryuk reduced cyclooxygenase-2 expression
Conclusions : According to this study, Jukryuk can protect neuron cells from injury by cerebrovascular ischemia
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KEYWORD
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Bambusae Caulis in Liquamen(Jukryk), neuroprotective effect, 4-vessel occlusion(4-VO), middle cerebral artery (MCA) ischemia
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